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Biological Small Angle ScatteringTheory and Practice$
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Eaton E. Lattman, Thomas D. Grant, and Edward H. Snell

Print publication date: 2018

Print ISBN-13: 9780199670871

Published to Oxford Scholarship Online: September 2018

DOI: 10.1093/oso/9780199670871.001.0001

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Examples of Biological Small Angle Scattering

Examples of Biological Small Angle Scattering

Chapter:
(p.193) 12 Examples of Biological Small Angle Scattering
Source:
Biological Small Angle Scattering
Author(s):

Eaton E. Lattman

Thomas D. Grant

Edward H. Snell

Publisher:
Oxford University Press
DOI:10.1093/oso/9780199670871.003.0012

In this chapter we illustrate the biological applications of small angle scattering. We cover examples of contrast matching has been used in the neutron case and with SAXS,. time-resolved studies that have helped reveal mechanism and how SAXS or SANS as a solution technique can access information missing from other studies, in particular residues that may be crystallographically undefined. We show examples of puting known structural information in context, and following large-scale functional changes or show when distinct populations co-exist in solution. The list of examples provided is not exhaustive and should be seen as a glimpse of the potential of biological mechanisms where SAXS or SANS can provide unique information complementary to other methods and help define function and mechanism.

Keywords:   Contrast matching, Time resolved, Missing information, Complexes, Interactions, Dynamics Disorder

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