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Textbook of Cancer Epidemiology$
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Hans-Olov Adami, David J. Hunter, Pagona Lagiou, and Lorelei Mucci

Print publication date: 2018

Print ISBN-13: 9780190676827

Published to Oxford Scholarship Online: February 2018

DOI: 10.1093/oso/9780190676827.001.0001

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Accomplishments in Cancer Epidemiology

Accomplishments in Cancer Epidemiology

(p.3) 1 Accomplishments in Cancer Epidemiology
Textbook of Cancer Epidemiology

Brian Macmahon

Oxford University Press

In his chapter “Accomplishments in Cancer Epidemiology,” Dr. MacMahon summarizes the history of the discipline, particularly the epidemiologic evidence on cigarette smoking, ionizing radiation, occupation, the physical and microbiologic environments, the reproductive experience of women, alcohol, and iatrogenic exposures as their bear on cancer risk in humans. Ionizing radiation as a cause of leukemia and cancer of the skin, breast, lung, and thyroid is discussed in detail, as well as liver cancer and myelogenous leukemia following exposure to the X-ray contrast medium thorotrast. Important occupational carcinogens include arsenic (lung cancer, bladder cancer), asbestos (lung cancer and mesothelioma), benzene (acute myeloid leukemia), chemical dyes (bladder cancer), chromium (lung cancer), nickel (nasal cancer), and vinyl chloride (angiosarcoma in the liver). The chapter ends with a broader overview of the other environmental causes of cancers that are reviewed in detail in the site-specific chapters.

Keywords:   history, cancer, epidemiology, environment, smoking, occupation, microbiologic exposure, reproductive experience, alcohol, iatrogenic exposure

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