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Immune Responses in the Nervous System$
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Nancy J. Rothwell

Print publication date: 1997

Print ISBN-13: 9781872748795

Published to Oxford Scholarship Online: March 2012

DOI: 10.1093/acprof:oso/9781872748795.001.0001

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Immune responses in the central nervous system in inflammatory demyelinating disease

Immune responses in the central nervous system in inflammatory demyelinating disease

Chapter:
(p.117) Chapter 6 Immune responses in the central nervous system in inflammatory demyelinating disease
Source:
Immune Responses in the Nervous System
Author(s):

M. L. Cuzner

T. Smith

Publisher:
Oxford University Press
DOI:10.1093/acprof:oso/9781872748795.003.0006

Detailed immunocytochemical studies of the inflammatory lesion in post-mortem brain from acute cases of multiple sclerosis (MS) reinforce the growing conviction that the immune reaction can be fuelled from within the central nervous system (CNS), although the kinetics of lymphocyte traffic between the blood and cerebrospinal fluid suggest ready access to the CNS compartment for activated T cells. Thus, the persistence of an immune stimulus and the intermittent reactivation of the immune system suggest that MS is a disease of immune regulation, but the nature of its relapsing/remitting course and the exact mechanisms of demyelination are as yet unresolved. This chapter discusses the nature of the cellular infiltrate, humoral immunity in MS, inflammation and demyelination in the CNS in model systems, pathogenetic mechanisms in MS, and regulatory mechanisms in MS.

Keywords:   multiple sclerosis, central nervous system, immune reactions, inflammation, demyelination, pathogenetic mechanisms, regulatory mechanisms, immune regulation, activated T cells

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