Jump to ContentJump to Main Navigation
Immune Responses in the Nervous System$
Users without a subscription are not able to see the full content.

Nancy J. Rothwell

Print publication date: 1997

Print ISBN-13: 9781872748795

Published to Oxford Scholarship Online: March 2012

DOI: 10.1093/acprof:oso/9781872748795.001.0001

Show Summary Details
Page of

PRINTED FROM OXFORD SCHOLARSHIP ONLINE (www.oxfordscholarship.com). (c) Copyright Oxford University Press, 2018. All Rights Reserved. Under the terms of the licence agreement, an individual user may print out a PDF of a single chapter of a monograph in OSO for personal use (for details see www.oxfordscholarship.com/page/privacy-policy).date: 21 September 2018

Immune responses in the central nervous system in inflammatory demyelinating disease

Immune responses in the central nervous system in inflammatory demyelinating disease

(p.117) Chapter 6 Immune responses in the central nervous system in inflammatory demyelinating disease
Immune Responses in the Nervous System

M. L. Cuzner

T. Smith

Oxford University Press

Detailed immunocytochemical studies of the inflammatory lesion in post-mortem brain from acute cases of multiple sclerosis (MS) reinforce the growing conviction that the immune reaction can be fuelled from within the central nervous system (CNS), although the kinetics of lymphocyte traffic between the blood and cerebrospinal fluid suggest ready access to the CNS compartment for activated T cells. Thus, the persistence of an immune stimulus and the intermittent reactivation of the immune system suggest that MS is a disease of immune regulation, but the nature of its relapsing/remitting course and the exact mechanisms of demyelination are as yet unresolved. This chapter discusses the nature of the cellular infiltrate, humoral immunity in MS, inflammation and demyelination in the CNS in model systems, pathogenetic mechanisms in MS, and regulatory mechanisms in MS.

Keywords:   multiple sclerosis, central nervous system, immune reactions, inflammation, demyelination, pathogenetic mechanisms, regulatory mechanisms, immune regulation, activated T cells

Oxford Scholarship Online requires a subscription or purchase to access the full text of books within the service. Public users can however freely search the site and view the abstracts and keywords for each book and chapter.

Please, subscribe or login to access full text content.

If you think you should have access to this title, please contact your librarian.

To troubleshoot, please check our FAQs , and if you can't find the answer there, please contact us .