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An Insider’s Guide to Clinical Trials$
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Curtis L Meinert

Print publication date: 2011

Print ISBN-13: 9780199742967

Published to Oxford Scholarship Online: September 2011

DOI: 10.1093/acprof:oso/9780199742967.001.0001

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Subgroup Analysis vs. Data Dredging

Subgroup Analysis vs. Data Dredging

Chapter:
(p.151) 17 Subgroup Analysis vs. Data Dredging
Source:
An Insider’s Guide to Clinical Trials
Author(s):

Curtis L. Meinert

Publisher:
Oxford University Press
DOI:10.1093/acprof:oso/9780199742967.003.0017

This chapter argues that the trouble with subgroup analyses is not in doing them, but rather in their interpretations. The fact that investigators do not report results of subgroup analyses does not mean that they were not done, as some would have you believe in regard to gender as a subgrouping variable. The belief that gender-by-treatment interactions are unrecognized because investigators do not look for them is usually false. Most journals have word and table limits. Authors are not likely to use their word and table budgets reporting subgroup analyses unless they think there is something to report. The best that can be expected is a sentence indicating that subgroup analyses were done for designated variables and that no differences were found.

Keywords:   clinical trial, subgroups, research data, subgroup analysis, gender

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