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Acids and Bases
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Acids and Bases: Solvent Effects on Acid-Base Strength

Brian G. Cox

Abstract

Acids and bases are ubiquitous in chemistry. Our understanding of them, however, is dominated by their behaviour in water. Transfer to non-aqueous solvents leads to profound changes in acid-base strengths and to the rates and equilibria of many processes: for example, synthetic reactions involving acids, bases, and nucleophiles; isolation of pharmaceutical actives through salt formation; formation of zwitter-ions in amino acids; and chromatographic separation of substrates. This book seeks to enhance our understanding of acids and bases by reviewing and analysing their behaviour in non-aqueous ... More

Keywords: acids, bases, solvent effects, protic solvents, aprotic solvents, dissociation constants, pKa-values, ion solvation, carbon acids, salt formation

Bibliographic Information

Print publication date: 2013 Print ISBN-13: 9780199670512
Published to Oxford Scholarship Online: May 2013 DOI:10.1093/acprof:oso/9780199670512.001.0001

Authors

Affiliations are at time of print publication.

Brian G. Cox, author
Pharmaceutical Development, AstraZeneca R&D

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