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AlcoholScience, Policy and Public Health$
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Peter Boyle, Paolo Boffetta, Albert B. Lowenfels, Harry Burns, Otis Brawley, Witold Zatonski, and Jürgen Rehm

Print publication date: 2013

Print ISBN-13: 9780199655786

Published to Oxford Scholarship Online: May 2013

DOI: 10.1093/acprof:oso/9780199655786.001.0001

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Liver disease

Liver disease

Chapter:
(p.269) Chapter 33 Liver disease
Source:
Alcohol
Author(s):

Michael H. Miller

Frank Sullivan

John F. Dillon

Publisher:
Oxford University Press
DOI:10.1093/acprof:oso/9780199655786.003.0033

Alcohol-related liver disease (ALD) represents a spectrum of liver damage caused by excessive alcohol consumption. The spectrum ranges from reversible fatty liver through to alcoholic hepatitis, alcohol-related cirrhosis, and hepatocellular carcinoma. The majority of heavy drinkers will not develop ALD despite apparently consuming similar amounts of alcohol in similar circumstances. The cause of this variation is probably multifactorial, and the combinations of factors differ between individuals, but accumulate to cross a threshold of response. This chapter discusses the mechanisms of alcohol-related liver damage and the clinical consequences this leads to.

Keywords:   alcohol consumption, alcohol intake, liver damage, fatty liver, alcoholic hepatitis, cirrhosis

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