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AlcoholScience, Policy and Public Health$
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Peter Boyle, Paolo Boffetta, Albert B. Lowenfels, Harry Burns, Otis Brawley, Witold Zatonski, and Jürgen Rehm

Print publication date: 2013

Print ISBN-13: 9780199655786

Published to Oxford Scholarship Online: May 2013

DOI: 10.1093/acprof:oso/9780199655786.001.0001

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Opioid pharmacogenetics of alcohol addiction

Opioid pharmacogenetics of alcohol addiction

Chapter:
(p.97) Chapter 11 Opioid pharmacogenetics of alcohol addiction
Source:
Alcohol
Author(s):

Wade Berrettini

Publisher:
Oxford University Press
DOI:10.1093/acprof:oso/9780199655786.003.0011

This chapter reviews clinical studies of naltrexone in alcoholism and pharmacogenetic studies of naltrexone clinical trials for alcohol addiction. There is growing interest in the association between μ-opioid receptors and addiction. Extensive data, across species, suggest that the 118G form of the μ-opioid receptor is characterized by decreased transcription and translation. Murine, primate, and human laboratory studies show that the 118G (or its species-specific homologue) variant permits alcohol to have a greater rewarding valence, leading to increased alcohol consumption. The human and rhesus data are equally convincing that naltrexone is able to blunt this greater rewarding signal.

Keywords:   opioids, alcohol reward, alcohol abuse, alcoholism, alcohol consumption, naltrexone, clinical studies

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