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Small Angle X-Ray and Neutron Scattering from Solutions of Biological Macromolecules
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Small Angle X-Ray and Neutron Scattering from Solutions of Biological Macromolecules

Dmitri I. Svergun, Michel H. J. Koch, Peter A. Timmins, and Roland P. May

Abstract

Small angle scattering of X-rays (SAXS) and neutrons (SANS) is an established method for the structural characterisation of biological objects in a broad size-range from individual macromolecules (proteins, nucleic acids, lipids) to large macromolecular complexes. The last decade has seen a renaissance in the study of low-resolution structure of native macromolecules in solution which provides overall particle shapes ab initio and is able to rapidly assess the oligomeric states of proteins and complexes. SAXS/SANS is complementary to the high-resolution methods of X-ray crystallography and nuc ... More

Keywords: structure, biological macromolecules, solution scattering, macromolecular complex, contrast variation, low-resolution shape, hybrid methods, intermolecular interactions, SAXS, SANS

Bibliographic Information

Print publication date: 2013 Print ISBN-13: 9780199639533
Published to Oxford Scholarship Online: December 2013 DOI:10.1093/acprof:oso/9780199639533.001.0001

Authors

Affiliations are at time of print publication.

Dmitri I. Svergun, author
Group Leader and Senior Scientist, European Molecular Biology Laboratory, Hamburg

Michel H. J. Koch, author
Department of Chemistry, University of Leuven

Peter A. Timmins, author
Long-term Visitor, Institut Laue-Langevin, Grenoble

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