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New Trends in the Physics and Mechanics of Biological SystemsLecture Notes of the Les Houches Summer School: Volume 92, July 2009$
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Martine Ben Amar, Alain Goriely, Martin Michael Müller, and Leticia Cugliandolo

Print publication date: 2011

Print ISBN-13: 9780199605835

Published to Oxford Scholarship Online: September 2011

DOI: 10.1093/acprof:oso/9780199605835.001.0001

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Mechanics of tumor growth: Multiphase models, adhesion, and evolving configurations

Mechanics of tumor growth: Multiphase models, adhesion, and evolving configurations

Chapter:
(p.177) 7 Mechanics of tumor growth: Multiphase models, adhesion, and evolving configurations
Source:
New Trends in the Physics and Mechanics of Biological Systems
Author(s):

Luigi Preziosi

Guido Vitale

Publisher:
Oxford University Press
DOI:10.1093/acprof:oso/9780199605835.003.0007

This chapter provides the basics to deduce multiphase models for the essential constituents present in tumours (cells, extracellular matrix, extracellular liquid, and possibly blood and limphatic vasculature). All the steps of the modelling procedure are explained in detail, special attention being paid to the meaning of all the different terms involved in the model. The chapter focuses on several mechanical aspects related to tumour growth, e.g., the activation of mechanotransduction pathways inside the cell, contact inhibition phenomena, the formation of stiffer fibrotic tissues, the adhesion phenomena characterizing the mechanical interaction between cells and between cell and extracellular matrix, and cell re-organization within the tissue.

Keywords:   multiphase models, biomechanics, adhesion, remodelling, fibrosis, mechanotransduction, contact inhibition, tumour growth, cancer modelling

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