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Decision Making, Affect, and LearningAttention and Performance XXIII$
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Mauricio R. Delgado, Elizabeth A. Phelps, and Trevor W. Robbins

Print publication date: 2011

Print ISBN-13: 9780199600434

Published to Oxford Scholarship Online: May 2011

DOI: 10.1093/acprof:oso/9780199600434.001.0001

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Role of striatal dopamine in the fast adaption of outcome-based decisions

Role of striatal dopamine in the fast adaption of outcome-based decisions

Chapter:
(p.349) Chapter 16 Role of striatal dopamine in the fast adaption of outcome-based decisions
Source:
Decision Making, Affect, and Learning
Author(s):

Roshan Cools

Publisher:
Oxford University Press
DOI:10.1093/acprof:oso/9780199600434.003.0016

The prefrontal cortex interacts with a set of deep brain subcortical structures, including in particular the striatum, to bias flexible decision making. The output of these fronto-striatal circuits is sensitive to modulation by brain dopamine. However, the relationship between dopamine and flexible decision making is complex and the effects of dopaminergic drugs are both baseline-dependent and outcome-specific. Specifically, opposite effects are observed on reward- and punishment-based reversal learning and in subjects with high and low baseline dopamine function. This chapter highlights two factors that may contribute to the large variability of dopaminergic drug effects on human cognition in general, and on the fast adaptation of outcome-predictions in particular. First, different effects are seen depending on the particular task demands under study and the associated neural mechanism, as illustrated by the contrasting effect of dopamine-enhancing drugs on the updating of reward- and punishment-predictions in Parkinson's Disease as well as in healthy volunteers. Second, drug effects depend on baseline levels of dopamine, as illustrated by a positron emission tomography study where drugs had opposite effects in low- and high-dopamine subjects.

Keywords:   prefrontal cortex, human brain, flexible decision making, dopamine, striatum, reversal learning, dopaminergic drugs, cognition

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