The hypothesis is that space‐time is what there is. W.V. Quine's ‘abstract objects’ are rejected. What exists should play some causal role (Graham Oddie's Eleatic Principle). The nature of space‐time is subject to scientific investigation (Wilfrid Sellars' distinction between the manifest and the scientific image of the world). Is there room for metaphysics? Yes, because a number of topic neutral notions (of which causality is an important instance) are contested by philosophers and scientists. As argued by C.B. Martin, metaphysics seeks a more abstract model of the world than that provided by science.
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