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Economic Evaluation in Child Health$
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Wendy Ungar

Print publication date: 2009

Print ISBN-13: 9780199547494

Published to Oxford Scholarship Online: February 2010

DOI: 10.1093/acprof:oso/9780199547494.001.0001

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Economic evaluations of newborn screening

Economic evaluations of newborn screening

Chapter:
(p.113) Chapter 6 Economic evaluations of newborn screening
Source:
Economic Evaluation in Child Health
Author(s):

Scott D. Grosse

Publisher:
Oxford University Press
DOI:10.1093/acprof:oso/9780199547494.003.06

Screening for metabolic, endocrine, and other diseases in newborns is performed through the laboratory analysis of dried blood spot specimens. This chapter reviews economic evaluations of newborn dried blood spot screening strategies published during 2002-07, focusing on the cost-effectiveness of screening for cystic fibrosis, congenital adrenal hyperplasia, and medium chain acyl-CoA dehydrogenase deficiency (MCADD). The use of tandem mass spectrometry (MS/MS) to detect MCADD is presented in detail, through examinations of the costs of screening and medical management, and of outcomes, including quality-adjusted life year (QALY) measurement, disability, and mortality. Ways to generate higher quality evidence are presented. The chapter concludes with a discussion of the use of economic evaluations to inform newborn screening policies.

Keywords:   newborn screening, metabolic disorders, tandem mass spectrometry, cost-effectiveness, QALY, health policy

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