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Economic Evaluation in Child Health$
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Wendy Ungar

Print publication date: 2009

Print ISBN-13: 9780199547494

Published to Oxford Scholarship Online: February 2010

DOI: 10.1093/acprof:oso/9780199547494.001.0001

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The use of value of information methods in the design and evaluation of clinical trials

The use of value of information methods in the design and evaluation of clinical trials

Chapter:
(p.91) Chapter 5 The use of value of information methods in the design and evaluation of clinical trials
Source:
Economic Evaluation in Child Health
Author(s):

Andrew R. Willan

Publisher:
Oxford University Press
DOI:10.1093/acprof:oso/9780199547494.003.05

This chapter illustrates the use of value of information methods in determining sample size for pediatric clinical trials and for summarizing trial results, underscoring the particular advantage these methods have for rare diseases in pediatrics. Based on incremental net benefit, a model for developing value of information methods is given. Solutions based on decision theory for determining optimal sample size under various assumptions are also presented. There then follows two examples illustrating the methods using data from pediatric trials — the first related to the use of calf lung surfactant in patients with pediatric acute hypoxemic respiratory failure and the second examining postoperative purulent otorrhea. The advantages of value of information methods are summarized in the last section.

Keywords:   value of information, sample size, clinical trials, net benefit, decision theory

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