Variation in disease by time, place, and person
A framework for analysis of genetic and environmental effects
This chapter emphasizes a systematic framework of analysis of disease variations, particularly to ensure that observations of variation are real, and not products of data errors and artifacts. The framework applies to all measures of disease frequency. Topics discussed include reasons for analysing disease variations: environment and genetics; introducing human genetic variation and genetic epidemiology; disease clustering and clusters in epidemiology; and applications of observations of disease variation.
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