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Ancestral Sequence Reconstruction$
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David A Liberles

Print publication date: 2007

Print ISBN-13: 9780199299188

Published to Oxford Scholarship Online: September 2008

DOI: 10.1093/acprof:oso/9780199299188.001.0001

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Using ancestral gene resurrection to unravel the evolution of protein function

Using ancestral gene resurrection to unravel the evolution of protein function

Chapter:
(p.183) CHAPTER 16 Using ancestral gene resurrection to unravel the evolution of protein function
Source:
Ancestral Sequence Reconstruction
Author(s):

Joseph W. Thornton

Jamie T. Bridgham

Publisher:
Oxford University Press
DOI:10.1093/acprof:oso/9780199299188.003.0016

This chapter reviews the use of ancestral gene resurrection to understand how the members of a biologically crucial gene family, the steroid hormone receptors, evolved their diverse and highly specific functions. It also discusses some methodological questions and concerns — particularly related to uncertainty in the reconstruction of ancestral sequences — and point to potential future directions for the budding field of ancestral gene resurrection. Topics covered include the evolution of molecular interactions, steroid hormones and their receptors, evolution of corticoid receptor specificity, and evolution of the MR-aldosterone interaction.

Keywords:   steroid hormone receptors, evolution, ancestral sequences, molecular interactions, corticoid receptors

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