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Ion Channels
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Ion Channels: From Structure to Function

James Kew and Ceri Davies

Abstract

Ion channels are intimately involved in the everyday physiological functions that enable us to live a full and varied life. When disease strikes, malfunction of ion channels or their dependent processes is often involved, either as the cause or effect of the illness. Thus, billions of dollars have been, and still are being, invested in research to understand the physiological and pathophysiological functions of ion channels in an attempt to develop novel therapeutic treatments for a wide range of diseases. This book provides a comprehensive overview of ion-channel structure and function. It co ... More

Keywords: ion channels, physiological functions, disease, therapeutic treatments, biophysical characterization, ligands, physiology, biophysics, localization, pharmacology

Bibliographic Information

Print publication date: 2009 Print ISBN-13: 9780199296750
Published to Oxford Scholarship Online: March 2012 DOI:10.1093/acprof:oso/9780199296750.001.0001

Authors

Affiliations are at time of print publication.

James Kew, editor
Director, Molecular and Cellular Biology, Schizophrenia & Cognitive Disorders Discovery Performance Unit, Neurosciences CEDD, GlaxoSmithKline, New Frontiers Science Park, Harlow, U.K.

Ceri Davies, editor
Mood and Anxiety Doisorders Discovery Performance Unit, Neurosciences CEDD, GlaxoSmithKline, Medicines Research Center, Via A Fleming, Verona, Italy

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Contents

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1 Ion channels

Derek Trezise, Tim Dale, and Martin Main

2.1 Voltage-gated K+ channels

Derek Trezise, Tim Dale, and Bernardo Rudy

2.2 Voltage-gated calcium channels

Joel Baumgart, and Edward Perez-Reyes

2.3 Voltage-gated sodium channels

Sulayman Dib-Hajj, and Tony Priestley

2.5 Hyperpolarization-activated cation channels

Mira Kuisle, and Anita Lüthi

3.1 Cys loop receptors

Dr James N. C. Kew, and Dr Ceri H. Davies

3.2 Glutamate receptors

Dr James N. C. Kew, and Dr Ceri H. Davies

3.3 ATP receptors

Dr James N. C. Kew, and Dr Ceri H. Davies

3.4 Others

Dr James N. C. Kew, and Dr Ceri H. Davies

4.1 Chloride channels activated by intracellular ligands

Arreola Jorge, Pablo Reyes Juan, Rosales-Saavedra Teresa, and Pérez-Cornejo Patricia

4.2 Cyclic nucleotide-gated ion channels

Zhengchao Wan, and Fangxiong Shi

4.3 KCa 1—KCa5 families

Morten Grunnet, Dorte Strøbæk, Søren-Peter Olesen, and Palle Christophersen

4.4 Kir family

Dr James N. C. Kew, and Dr Ceri H. Davies

4.5 Ryanodine receptors

Stephan Lehnart, and Andrew Marks

4.6 IP3 receptors

Randen Patterson, and Damian van Rossum

5.1 Transient receptor potential channels

Grzegorz Owsianik, Thomas Voets, and Bernd Nilius

5.2 Connexins and pannexins

Hartfiel Elizabeth, Weil Annette, Uney James, and Southam Eric

End Matter