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Family mattersDesigning, analysing and understanding family based studies in life course epidemiology$
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Deborah A. Lawlor and Gita D. Mishra

Print publication date: 2009

Print ISBN-13: 9780199231034

Published to Oxford Scholarship Online: September 2009

DOI: 10.1093/acprof:oso/9780199231034.001.0001

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Theoretical underpinning for the use of intergenerational studies in life course epidemiology

Theoretical underpinning for the use of intergenerational studies in life course epidemiology

Chapter:
(p.13) Chapter 2 Theoretical underpinning for the use of intergenerational studies in life course epidemiology
Source:
Family matters
Author(s):

Debbie A Lawlor

Sam Leary

George Davey Smith

Publisher:
Oxford University Press
DOI:10.1093/acprof:oso/9780199231034.003.0002

Intergenerational studies have been widely used in life course epidemiology both to examine primary research hypotheses and to explore underlying mechanisms for established associations. This chapter describes the theoretical underpinning for using different types of intergenerational studies in life course epidemiology and discusses how results from such studies should be interpreted. Specifically, it considers the use and interpretation of cousin, sibling, and twin intergenerational studies; egg donation/surrogate mother intergenerational studies; maternal-paternal comparisons; and intergenerational migrant studies and Mendelian randomization in intergenerational studies in life course epidemiology.

Keywords:   developmental origins, birth weight, genetic epidemiology, causality, mechanisms, cousin-studies, egg donation, surrogate mother studies, Mendelian randomization

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