Jump to ContentJump to Main Navigation
Human Genetic Diversity$
Users without a subscription are not able to see the full content.

Julian C. Knight

Print publication date: 2009

Print ISBN-13: 9780199227693

Published to Oxford Scholarship Online: September 2009

DOI: 10.1093/acprof:oso/9780199227693.001.0001

Mobile DNA elements

Chapter:
(p.195) Chapter 8 Mobile DNA elements
Source:
Human Genetic Diversity
Author(s):

Julian C. Knight

Publisher:
Oxford University Press
DOI:10.1093/acprof:oso/9780199227693.003.0008

In this chapter the remarkable extent of mobile DNA elements within the human genome is reviewed. The concept of mobile DNA elements as genomic parasites is discussed including how such elements are now almost exclusively inactive. The analysis of how mobile DNA elements provide a 'fossil record' of past transposition events is reviewed together with the evolutionary insights this has provided. The dispersal and accumulation of mobile DNA elements in eukaryotes is described together including how this has contributed to the complexity and plasticity of our genome. DNA transposons, L1 retrotransposable elements, and Alu elements are all reviewed together with associations with genetic disease. Polymorphism seen among recent Alu and other mobile DNA elements is discussed including how this has contributed to our understanding of human population genetics and evolutionary history. Evidence to support a recent African origins hypothesis is reviewed.

Keywords:   mobile DNA elements, retrotransposons, Alu elements, transposition, DNA transposons, long interspersed elements, short interspersed elements, recent African origins hypothesis, evolution, retrotransposable element

Oxford Scholarship Online requires a subscription or purchase to access the full text of books within the service. Public users can however freely search the site and view the abstracts and keywords for each book and chapter.

Please, subscribe or login to access full text content.

If you think you should have access to this title, please contact your librarian.

To troubleshoot, please check our FAQs , and if you can't find the answer there, please contact us .

Users without a subscription are not able to see the full content. Please, subscribe or login to access all content.