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A Decade of HAARTThe Development and Global Impact of Highly Active Antiretroviral Therapy$
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José M. Zuniga, Alan Whiteside, Amin Ghaziani, and John G. Bartlett

Print publication date: 2008

Print ISBN-13: 9780199225859

Published to Oxford Scholarship Online: September 2009

DOI: 10.1093/acprof:oso/9780199225859.001.0001

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The OPTIMA Cohort

The OPTIMA Cohort

Chapter:
(p.219) Chapter 15 The OPTIMA Cohort
Source:
A Decade of HAART
Author(s):

Mark Holodniy

Publisher:
Oxford University Press
DOI:10.1093/acprof:oso/9780199225859.003.0015

This chapter reviews the Options in Management with Antiretrovirals (OPTIMA) study. OPTIMA study is the first tri-national collaboration between the US Department of Veterans Affairs (VA), Canadian Institutes for Health Research, and the UK Medical Research Council. It is a prospective, randomized, 2-factorial design study looking at the clinical utility of a three-month antiretroviral drug-free period (ARDFP), and whether there is a difference in effectiveness between standard and ‘mega-regimens’ (five or more active antiretroviral drugs).

Keywords:   highly active antiretroviral therapy, cohort study, Options in Management with Antiretrovirals, HIV/AIDS research

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