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Macromolecular Crystallization and Crystal Perfection
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Macromolecular Crystallization and Crystal Perfection

Naomi E. Chayen, John R. Helliwell, and Edward H. Snell

Abstract

Structural crystallography provides key information to understand the mechanism involved for biological processes. The technique requires high‐quality crystals. The book Macromolecular crystallization and crystal perfection covers the techniques to get these high quality crystals and then obtain the best structural data from them. We focus on two areas, the crystal and the diffraction experiment. We briefly address crystallization theory and then focus on practical crystallization strategies discussing screening and optimization. Where high quality crystals are not initially obtained, remediat ... More

Keywords: crystallization, crystal growth methods, molecular biology, crystal growth monitoring, crystal perfection, crystal perfection assessment, short range order, long range order, twinning, lattice defects, remediation methods, powder diffraction, single molecule diffraction, synchrotron X‐ray sources, X‐ray Free Electron Lasers, Neutron beams, radiation damage in macromolecular crystals, biophysics, structural biology, structural chemistry, structural genomics

Bibliographic Information

Print publication date: 2010 Print ISBN-13: 9780199213252
Published to Oxford Scholarship Online: May 2010 DOI:10.1093/acprof:oso/9780199213252.001.0001

Authors

Affiliations are at time of print publication.

Naomi E. Chayen, author
Department of Biomolecular Medicine, Imperial College London, UK

John R. Helliwell, author
School of Chemistry, University of Manchester, UK

Edward H. Snell, author
Hauptman-Woodward Institute, SUNY-Buffalo, USA.

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