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The CRF Signal
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The CRF Signal: Uncovering an Information Molecule

Jay Schulkin

Abstract

This book discusses just how diverse a peptide corticotrophin-releasing factor (CRF) is, as demonstrated by its presence in various tissues in the body, including the skin, the placenta, and various regions of the brain. As Dobzhansky (1962) noted, in light of Darwin (1874), and beyond, CRF must be placed in the larger world of regulatory biology. Evolutionary trends do not proceed in a continuous one-dimensional direction; there are starts, turns, and abrupt ends. The study of CRF is mostly about diverse functions in physiological and behavioral regulation of the internal milieu and adapting ... More

Keywords: CRF, corticotrophin-releasing factor, evolution, diverse function, peptide, brain, information molecule, addiction, fear, anxiety

Bibliographic Information

Print publication date: 2017 Print ISBN-13: 9780198793694
Published to Oxford Scholarship Online: June 2017 DOI:10.1093/acprof:oso/9780198793694.001.0001

Authors

Affiliations are at time of print publication.

Jay Schulkin, author
Research Professor, Georgetown University