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Sleep and Brain Plasticity$
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Pierre Maquet, Carlyle Smith, and Robert Stickgold

Print publication date: 2003

Print ISBN-13: 9780198574002

Published to Oxford Scholarship Online: September 2009

DOI: 10.1093/acprof:oso/9780198574002.001.0001

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Sleep Modulation of the Expression of Plasticity Markers

Sleep Modulation of the Expression of Plasticity Markers

(p.363) Chapter 17 Sleep Modulation of the Expression of Plasticity Markers
Sleep and Brain Plasticity

James M. Krueger

Ferenc Obál Jr.

Joseph W. Harding

John W. Wright

Lynn Churchill

Oxford University Press

This chapter shows that various compounds (such as NO and various hormones, and cytokines) share three main functional features. They are released in response to neural activity; they are somnogenic; and they trigger a cascade of events involved in neural plasticity. After reviewing the somnogenic factors which are released in an activity-dependent manner, the chapter focuses on two examples, more closely related to neural plasticity: the expression of nerve growth factor (NGF), a neurotrophin involved in neural plasticity, which is modulated by sleep/sleep deprivation only in neurones with an elevated activity during previous waking periods; and metalloproteinase-9 which is involved in the interaction between neurones and extracellular matrix, a critical feature in neural plasticity. It is shown that sleep deprivation modifies the cerebral expression of the metalloproteinase-9 induced by spatial learning.

Keywords:   sleep, neural activity, nerve growth factor, metalloproteinase-9

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