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Sleep and Brain Plasticity$
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Pierre Maquet, Carlyle Smith, and Robert Stickgold

Print publication date: 2003

Print ISBN-13: 9780198574002

Published to Oxford Scholarship Online: September 2009

DOI: 10.1093/acprof:oso/9780198574002.001.0001

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Sleep Modulation of the Expression of Plasticity Markers

Sleep Modulation of the Expression of Plasticity Markers

Chapter:
(p.363) Chapter 17 Sleep Modulation of the Expression of Plasticity Markers
Source:
Sleep and Brain Plasticity
Author(s):

James M. Krueger

Ferenc Obál Jr.

Joseph W. Harding

John W. Wright

Lynn Churchill

Publisher:
Oxford University Press
DOI:10.1093/acprof:oso/9780198574002.003.0018

This chapter shows that various compounds (such as NO and various hormones, and cytokines) share three main functional features. They are released in response to neural activity; they are somnogenic; and they trigger a cascade of events involved in neural plasticity. After reviewing the somnogenic factors which are released in an activity-dependent manner, the chapter focuses on two examples, more closely related to neural plasticity: the expression of nerve growth factor (NGF), a neurotrophin involved in neural plasticity, which is modulated by sleep/sleep deprivation only in neurones with an elevated activity during previous waking periods; and metalloproteinase-9 which is involved in the interaction between neurones and extracellular matrix, a critical feature in neural plasticity. It is shown that sleep deprivation modifies the cerebral expression of the metalloproteinase-9 induced by spatial learning.

Keywords:   sleep, neural activity, nerve growth factor, metalloproteinase-9

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