Molecular Mechanisms of Memory Consolidation
This chapter describes how neuromodulators and electrophysiological phenomena in the hippocampus during NREM and REM sleep affect intracellular signaling pathways that are known to mediate memory consolidation. The hippocampus appears to be a locus for consolidation during sleep, because it is required for the consolidation of spatial learning and contextual fear conditioning and these tasks require sleep for consolidation. During this period of sleep, replay of activity occurs in the hippocampus in oscillations that have the ability to alter synaptic plasticity, perhaps via molecular cascades involved in LTP.
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