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Sleep and Brain Plasticity$
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Pierre Maquet, Carlyle Smith, and Robert Stickgold

Print publication date: 2003

Print ISBN-13: 9780198574002

Published to Oxford Scholarship Online: September 2009

DOI: 10.1093/acprof:oso/9780198574002.001.0001

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Molecular Mechanisms of Memory Consolidation

Molecular Mechanisms of Memory Consolidation

(p.295) Chapter 15 Molecular Mechanisms of Memory Consolidation
Sleep and Brain Plasticity

Kevin M. Hellman

Ted Abel

Oxford University Press

This chapter describes how neuromodulators and electrophysiological phenomena in the hippocampus during NREM and REM sleep affect intracellular signaling pathways that are known to mediate memory consolidation. The hippocampus appears to be a locus for consolidation during sleep, because it is required for the consolidation of spatial learning and contextual fear conditioning and these tasks require sleep for consolidation. During this period of sleep, replay of activity occurs in the hippocampus in oscillations that have the ability to alter synaptic plasticity, perhaps via molecular cascades involved in LTP.

Keywords:   sleep, cognitive neuroscience, memory, hippocampus, NMDA receptors

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