Genome instability and accelerated aging
The almost general consensus that aging is caused by the accumulation of unrepaired somatic damage has yielded models for aging based on the inactivation or weakening of somatic maintenance systems. Almost all these models are based on human and mouse mutants harbouring defects in genome maintenance. This chapter discusses such models, their molecular basis, the possible nature of the pro-aging processes underlying the phenotypes observed, and their validity in representing genuine aging processes as they take place in normal animals.
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