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Critical Appraisal of Epidemiological Studies and Clinical Trials$
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Mark Elwood

Print publication date: 2007

Print ISBN-13: 9780198529552

Published to Oxford Scholarship Online: September 2009

DOI: 10.1093/acprof:oso/9780198529552.001.0001

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Critical appraisal of a large population-based case–control study

Chapter:
(p.471) Chapter 15 Critical appraisal of a large population-based case–control study
Source:
Critical Appraisal of Epidemiological Studies and Clinical Trials
Author(s):

J. Mark Elwood

Publisher:
Oxford University Press
DOI:10.1093/acprof:oso/9780198529552.003.15

This chapter presents an example of the application of the scheme for critical appraisal: large population-based case-control study entitled ‘Risk of breast cancer in relation to lifetime alcohol consumption’, published in the Journal of the National Cancer Institute in 1995. This large case-control study has shown a regular positive association between recorded alcohol intake and breast cancer risk. The results are generally consistent with the results of other observational studies, most of which, however, would be open to the same limitations.

Keywords:   confounding, causal relationships, breast cancer, alcohol consumption

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