Jump to ContentJump to Main Navigation
Critical Appraisal of Epidemiological Studies and Clinical Trials$
Users without a subscription are not able to see the full content.

Mark Elwood

Print publication date: 2007

Print ISBN-13: 9780198529552

Published to Oxford Scholarship Online: September 2009

DOI: 10.1093/acprof:oso/9780198529552.001.0001

Subscriber Login

Forgotten your password?

Critical appraisal of a matched case–control study

Chapter:
(p.453) Chapter 14 Critical appraisal of a matched case–control study
Source:
Critical Appraisal of Epidemiological Studies and Clinical Trials
Author(s):

J. Mark Elwood

Publisher:
Oxford University Press
DOI:10.1093/acprof:oso/9780198529552.003.14

This chapter presents an example of the application of the scheme for critical appraisal: a small matched case-control study entitled ‘Increased risk of endometrial carcinoma among users of conjugated estrogens’, published in the New England Journal of Medicine in 1975. The study is the first publication showing an important relationship between a disease and a widely used drug. It was chosen because it is now of historical importance, and is a good example of an individually matched study with several issues of interpretation. In addition, it shows an interesting way of assessing confounding, which is valid although not usually used in current studies.

Keywords:   confounding, case control studies, causal relationships, endometrial carcinoma, estrogen

Oxford Scholarship Online requires a subscription or purchase to access the full text of books within the service. Public users can however freely search the site and view the abstracts and keywords for each book and chapter.

Please, subscribe or login to access full text content.

If you think you should have access to this title, please contact your librarian.

To troubleshoot, please check our FAQs , and if you can't find the answer there, please contact us .