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Critical Appraisal of Epidemiological Studies and Clinical Trials$
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Mark Elwood

Print publication date: 2007

Print ISBN-13: 9780198529552

Published to Oxford Scholarship Online: September 2009

DOI: 10.1093/acprof:oso/9780198529552.001.0001

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Critical appraisal of a randomized trial of a preventive agent

Chapter:
(p.387) Chapter 11 Critical appraisal of a randomized trial of a preventive agent
Source:
Critical Appraisal of Epidemiological Studies and Clinical Trials
Author(s):

J. Mark Elwood

Publisher:
Oxford University Press
DOI:10.1093/acprof:oso/9780198529552.003.0011

This chapter presents an example of the application of the scheme for critical appraisal: a randomized clinical trial entitled ‘Prevention of neural tube defects: results of the Medical Research Council Vitamin Study’, published in The Lancetin 1991. This large individually randomized trial has produced a result which has extremely high internal validity, with observation bias and confounding being ruled out as alternative explanations.

Keywords:   randomized trial, critical appraisal, neural tube defects, internal validity

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