Critical appraisal of a randomized trial of a preventive agent
This chapter presents an example of the application of the scheme for critical appraisal: a randomized clinical trial entitled ‘Prevention of neural tube defects: results of the Medical Research Council Vitamin Study’, published in The Lancetin 1991. This large individually randomized trial has produced a result which has extremely high internal validity, with observation bias and confounding being ruled out as alternative explanations.
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