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The Motoneurone and its Muscle Fibres$
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Daniel Kernell

Print publication date: 2006

Print ISBN-13: 9780198526551

Published to Oxford Scholarship Online: September 2009

DOI: 10.1093/acprof:oso/9780198526551.001.0001

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Denervation and reinnervation

Denervation and reinnervation

(p.203) Chapter 10 Denervation and reinnervation
The Motoneurone and its Muscle Fibres

Daniel Kernell

Oxford University Press

This chapter is concerned with the slow processes and cellular adaptations taking place after the transection of motor axons. For axotomized motoneurones, changes occur in their morphology, membrane properties, and synaptic cover. Denervated muscle fibres become atrophic and weak, their membrane properties are altered and they may become spontaneously active (fibrillation). After transection, peripheral motor axons will regenerate and, ultimately, reinnervate denervated muscle fibres that they might come across. Such reinnervation will promote a change of muscle fibre properties back toward normal. In very young mammals, but generally not in adults, regenerating peripheral axons may be (partly) capable of finding their own original target muscles. Properties of muscle fibres may change after reinnervation by types of motoneurones other than their original ones (cross-reinnervation experiments). In partially denervated muscles, collateral reinnervation may occur by sprouting of new collaterals from surviving motor axons.

Keywords:   motoneurone axotomy, muscle denervation, fibrillation, axonal regeneration, axonal target selection, muscle reinnervation, muscle cross-reinnervation, axonal sprouting

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