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Brain Damage, Brain Repair$
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James W. Fawcett, Anne E. Rosser, and Stephen B. Dunnett

Print publication date: 2002

Print ISBN-13: 9780198523376

Published to Oxford Scholarship Online: March 2012

DOI: 10.1093/acprof:oso/9780198523376.001.0001

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Trophic factors

Trophic factors

Chapter:
(p.127) 9 Trophic factors
Source:
Brain Damage, Brain Repair
Author(s):

James W. Fawcett

Anne E. Rosser

Stephen B. Dunnett

Publisher:
Oxford University Press
DOI:10.1093/acprof:oso/9780198523376.003.0009

The developing nervous system produces about twice as many neurons as will survive into adulthood, and then at the end of development, around the time of birth in mammals, there is a short period termed the ‘period of ontogenetic cell death’ during which about half the neurones die. Trophic factors have a well-characterised role in the control of this process. The first trophic factor to be characterised was nerve growth factor (NGF): Rita Levi-Montalcini and Stanley Cohen received a Nobel prize for their pioneering work in the identification of this molecule. Subsequently, many other neuronal trophic factors have been discovered, many of them mentioned later in this chapter, but NGF has provided the prototype for all that followed.

Keywords:   nerve growth factor, trophic factor, nervous system, neurons, cell death, tissue culture

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