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Brain Damage, Brain Repair$
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James W. Fawcett, Anne E. Rosser, and Stephen B. Dunnett

Print publication date: 2002

Print ISBN-13: 9780198523376

Published to Oxford Scholarship Online: March 2012

DOI: 10.1093/acprof:oso/9780198523376.001.0001

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Gene therapy

Gene therapy

With Stacey Efstathiou

Chapter:
(p.357) 26 Gene therapy
Source:
Brain Damage, Brain Repair
Author(s):

James W. Fawcett

Anne E. Rosser

Stephen B. Dunnett

Publisher:
Oxford University Press
DOI:10.1093/acprof:oso/9780198523376.003.0026

Genetic engineering may be defined as the development of techniques to manipulate the genotype of cells or organisms in order to modify their phenotype. Gene therapy is the use of those techniques to alleviate injury, repair damage, or change the course of a disease. These techniques are potentially applicable to all living cells, not just cells of the nervous system, and indeed much of what we presently know about genetic engineering and gene therapy comes from the study of other cells, organs, and systems of the body, such as identifying and manipulating genes that predispose to cell proliferation and cause cancer (‘oncogenes’). Gene therapy can have various goals. The two major ones are the correction of genetic disease, and the delivery of genes to the nervous system to alter a disease process.

Keywords:   genetic engineering, genotypes, phenotype, living cells, nervous system, cell proliferation, genetic disease

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