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Brain Damage, Brain Repair$
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James W. Fawcett, Anne E. Rosser, and Stephen B. Dunnett

Print publication date: 2002

Print ISBN-13: 9780198523376

Published to Oxford Scholarship Online: March 2012

DOI: 10.1093/acprof:oso/9780198523376.001.0001

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Stem cells

Stem cells

Chapter:
(p.344) 25 Stem cells
Source:
Brain Damage, Brain Repair
Author(s):

James W. Fawcett

Anne E. Rosser

Stephen B. Dunnett

Publisher:
Oxford University Press
DOI:10.1093/acprof:oso/9780198523376.003.0025

Until fairly recently, interest in stem cells was restricted within neurobiology to studies on the fundamental principles of neural development, although in other fields (such as oncology) they have been a topic of major investigation for understanding the principles surrounding control of cell proliferation, in particular as it relates to the haematopoietic system and leukaemia. However this situation has changed rapidly in the last decade, not least because of the realisation that if we can understand the lineages of cell birth during normal development, then maybe we can manipulate neural precursors in vitro, allowing for potentially unlimited expansion and controlled differentiation of different populations of neuronal cells both in vitro and in vivo. This then would offer the potential of providing unlimited supplies of precisely specified cells for transplantation, and open up other, completely new, strategies for repair.

Keywords:   stem cells, neural development, cell proliferation, haematopoietic system, leukaemia, transplantation

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