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Brain Damage, Brain Repair$
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James W. Fawcett, Anne E. Rosser, and Stephen B. Dunnett

Print publication date: 2002

Print ISBN-13: 9780198523376

Published to Oxford Scholarship Online: March 2012

DOI: 10.1093/acprof:oso/9780198523376.001.0001

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Axon regeneration in the CNS

Axon regeneration in the CNS

Chapter:
(p.301) 22 Axon regeneration in the CNS
Source:
Brain Damage, Brain Repair
Author(s):

James W. Fawcett

Anne E. Rosser

Stephen B. Dunnett

Publisher:
Oxford University Press
DOI:10.1093/acprof:oso/9780198523376.003.0022

This chapter describes the efforts that have been made to date to persuade axons in the CNS to regrow, and the resulting re-innervation of terminal structures and behavioural recovery. The success or failure of axon regeneration depends on a balance of positive and negative factors. On the one hand, the CNS environment produces several molecules that are inhibitory to growth, many of which increase following injury, and on the other hand, CNS axons are attempting with variable vigour to regrow through this inhibitory environment. It follows that if one wishes to encourage axon regeneration, one might do so either by making the CNS environment less inhibitory, or by making the axons better able to regrow.

Keywords:   axon regeneration, CNS, behavioural recovery, CNS axons, injury, inhibitory environment

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