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Brain Damage, Brain Repair$
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James W. Fawcett, Anne E. Rosser, and Stephen B. Dunnett

Print publication date: 2002

Print ISBN-13: 9780198523376

Published to Oxford Scholarship Online: March 2012

DOI: 10.1093/acprof:oso/9780198523376.001.0001

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Remyelination

Remyelination

By Robin Franklin

Chapter:
(p.205) 15 Remyelination
Source:
Brain Damage, Brain Repair
Author(s):

James W. Fawcett

Anne E. Rosser

Stephen B. Dunnett

Publisher:
Oxford University Press
DOI:10.1093/acprof:oso/9780198523376.003.0015

Demyelination is unusual in the spectrum of pathological processes that affect the central nervous system (CNS) in that it may be followed by a spontaneous regenerative process. This process, termed remyelination, involves re-investing demyelinated axons with new myelin sheaths (or internodes), and has been described in a number of experimental models, as well as in naturally-occurring demyelinating disease—most notably the acute lesions of multiple sclerosis. Remyelination allows the axon to transmit action potentials by saltatory conduction, a property that is lost in demyelination.

Keywords:   demyelination, pathological processes, central nervous system, regenerative process, remyelination, acute lesions

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