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Brain Damage, Brain Repair$
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James W. Fawcett, Anne E. Rosser, and Stephen B. Dunnett

Print publication date: 2002

Print ISBN-13: 9780198523376

Published to Oxford Scholarship Online: March 2012

DOI: 10.1093/acprof:oso/9780198523376.001.0001

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Biochemical plasticity

Biochemical plasticity

Chapter:
(p.196) 14 Biochemical plasticity
Source:
Brain Damage, Brain Repair
Author(s):

James W. Fawcett

Anne E. Rosser

Stephen B. Dunnett

Publisher:
Oxford University Press
DOI:10.1093/acprof:oso/9780198523376.003.0014

Many events can alter the neurotransmitter phenotype of central nervous system (CNS) neurones. For instance, most neurones down-regulate their neurotransmitters and the enzymes that make them after axotomy or other forms of damage. Neurotrophins tend to cause neurons to upregulate their neurotransmitter phenotype or even change it, and neurotrophins often prevent the downregulation of neurotransmitter phenotype after damage. There are so many examples of these types of behaviour that it would not be sensible in this book to try and detail them all. However, there are two particular experimental models in which neuroplasticity of this type has been analysed in detail, and this chapter describes them.

Keywords:   central nervous system, neurones, neurotransmitter phenotype, axotomy, downregulation, neuroplasticity

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