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Brain Damage, Brain Repair$
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James W. Fawcett, Anne E. Rosser, and Stephen B. Dunnett

Print publication date: 2002

Print ISBN-13: 9780198523376

Published to Oxford Scholarship Online: March 2012

DOI: 10.1093/acprof:oso/9780198523376.001.0001

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Failure of CNS regeneration

Failure of CNS regeneration

Chapter:
(p.155) 12 Failure of CNS regeneration
Source:
Brain Damage, Brain Repair
Author(s):

James W. Fawcett

Anne E. Rosser

Stephen B. Dunnett

Publisher:
Oxford University Press
DOI:10.1093/acprof:oso/9780198523376.003.0012

Axons in the mammalian peripheral nervous system (PNS) regenerate well. Axons in the adult mammalian central nervous system (CNS), however, do not spontaneously regenerate, with the result that any injury that cuts axons, such as spinal-cord injury, will not recover. Clearly a central feature of CNS repair will have to be the induction of axon regeneration. In principle, axon growth is a collaborative process that involves a dialogue between the axon and the environment it is trying to penetrate. Whether an axon will regenerate or not, therefore, depends on the regenerative efforts made by the axon, on the inhibitory or permissive molecules in the environment, and on the receptors for these molecules on the axonal surface. This chapter examines these various factors and their effects on CNS axon regeneration.

Keywords:   peripheral nervous system, axon regeneration, central nervous system, CNS regeneration, axonal surface, permissive molecules

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