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Brain Damage, Brain Repair$
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James W. Fawcett, Anne E. Rosser, and Stephen B. Dunnett

Print publication date: 2002

Print ISBN-13: 9780198523376

Published to Oxford Scholarship Online: March 2012

DOI: 10.1093/acprof:oso/9780198523376.001.0001

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Death and survival in the nervous system

Death and survival in the nervous system

Chapter:
(p.3) 1 Death and survival in the nervous system
Source:
Brain Damage, Brain Repair
Author(s):

James W. Fawcett

Anne E. Rosser

Stephen B. Dunnett

Publisher:
Oxford University Press
DOI:10.1093/acprof:oso/9780198523376.003.0001

It is only in recent years that we have come to realise how important is the part played by cell death in the development, homeostasis, and injury responses of the nervous system. During development excess neurons and glia are produced, and many then die to leave behind the required number of cells. In the mature nervous system there are progenitor cells constantly dividing, the progeny either dying or differentiating, and following injury there is extensive neuronal and glial cell death. This chapter covers the basic biology of cell survival and death, providing a background for the other chapters of this book.

Keywords:   nervous system, cell death, homeostasis, injury responses, neurones, progenitor cells

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