It is not surprising that the cornea possesses the most dense sensory innervation of the body. It has been estimated that the cornea contains 300–600 times more sensory endings than the skin and 20–40 times more than the tooth pulp. As discussed in this chapter, most of this innervation appears to be nociceptive in nature. This abundance in nociceptive terminals, together with the absence of blood vessels and the structural simplicity of the supporting tissues, makes the cornea a good model for analyzing the morphological and functional properties of peripheral nociceptors.
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