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Macromolecular Crystallographyconventional and high-throughput methods$
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Mark R. Sanderson and Jane V. Skelly

Print publication date: 2007

Print ISBN-13: 9780198520979

Published to Oxford Scholarship Online: September 2007

DOI: 10.1093/acprof:oso/9780198520979.001.0001

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Solving the phase problem using isomorphous replacement

Solving the phase problem using isomorphous replacement

Chapter:
(p.87) CHAPTER 6 Solving the phase problem using isomorphous replacement
Source:
Macromolecular Crystallography
Author(s):

Sherin S. Abdel-Meguid

Publisher:
Oxford University Press
DOI:10.1093/acprof:oso/9780198520979.003.0006

This chapter begins with a discussion of the theoretical basis of isomorphous replacement. It then discusses the selection of heavy-atom reagents, heavy atoms and their ligands, preparation of heavy-atom derivatives, determination of heavy-atom positions, and refinement of heavy-atom positions.

Keywords:   isomorphous replacement, heavy atoms, crystallography, ligands, heavy-atom position

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