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Macromolecular Crystallographyconventional and high-throughput methods$
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Mark R. Sanderson and Jane V. Skelly

Print publication date: 2007

Print ISBN-13: 9780198520979

Published to Oxford Scholarship Online: September 2007

DOI: 10.1093/acprof:oso/9780198520979.001.0001

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Macromolecular crystallography in drug design

Macromolecular crystallography in drug design

Chapter:
(p.265) CHAPTER 17 Macromolecular crystallography in drug design
Source:
Macromolecular Crystallography
Author(s):

Sherin S. Abdel-Meguid

Publisher:
Oxford University Press
DOI:10.1093/acprof:oso/9780198520979.003.0017

This chapter discusses macromolecular crystallography in drug discovery. Currently, all large and most small pharmaceutical and biotechnology companies have invested in macromolecular crystallography, with protein crystallography now an integral tool of drug discovery. During the last twenty years, the term rational drug design has slowly been replaced with the more precise term structure-based drug design (SBDD).

Keywords:   drug development, macromolecular crystallography, structure-based drug design, SBDD

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