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Macromolecular Crystallography
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Macromolecular Crystallography: conventional and high-throughput methods

Mark R. Sanderson and Jane V. Skelly

Abstract

Macromolecular crystallography is the study of macromolecules (proteins and nucleic acids) using X-ray crystallographic techniques in order to determine their molecular structure. The knowledge of accurate molecular structures is a pre-requisite for rational drug design, and for structure-based function studies to aid the development of effective therapeutic agents and drugs. The successful determination of the complete genome (genetic sequence) of several species (including humans) has recently directed scientific attention towards identifying the structure and function of the complete comple ... More

Keywords: macromolecules, proteins, nucleic acids, X-ray, crystallographic techniques, molecular structure, rational drug design, structure-based function studies, therapeutic agents

Bibliographic Information

Print publication date: 2007 Print ISBN-13: 9780198520979
Published to Oxford Scholarship Online: September 2007 DOI:10.1093/acprof:oso/9780198520979.001.0001

Authors

Affiliations are at time of print publication.

Mark R. Sanderson, editor
Randall Division of Cell and Molecular Biophysics, King's College London, UK.

Jane V. Skelly, editor
Medway School of Science, University of Greenwich, UK.

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Contents

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CHAPTER 1 Classical cloning, expression, and purification

Jane Skelly, Maninder K. Sohi, and Thil Batuwangala

CHAPTER 2 High-throughput cloning, expression, and purification

Raymond J. Owens, Joanne E. Nettleship, Nick S. Berrow, Sarah Sainsbury, A. Radu Aricescu, David I. Stuart, and David K. Stammers

CHAPTER 4 First analysis of macromolecular crystals

Sherin S. Abdel-Meguid, David Jeruzalmi, and Mark R. Sanderson

CHAPTER 8 MAD phasing

H. M. Krishna Murthy

CHAPTER 10 Phase refinement through density modification

Jan Pieter Abrahams, Jasper R. Plaisier, Steven Ness, and Navraj S. Pannu

CHAPTER 12 High-throughput crystallographic data collection at synchrotrons

Stephen R. Wasserman, David W. Smith, Kevin L. D'Amico, John W. Koss, Laura L. Morisco, and Stephen K. Burley

CHAPTER 14 RNA crystallogenesis

Benoît Masquida, Boris François, Andreas Werner, and Eric Westhof

CHAPTER 16 Virus crystallography

Elizabeth E. Fry, Nicola G. A. Abrescia, and David I. Stuart

End Matter