Signal reception: G protein-coupled receptors
G protein-coupled receptors (GPCRs) transduce extracellular signals into a multitude of intracellular changes including changes in electrical activity, levels of second messengers, secretion, morphology, growth, and differentiation. Understanding how the common structural features of these receptors allow such controlled yet complex signalling patterns is a fundamental question in neurobiology. This chapter discusses the overall structural features, receptor-ligand interactions, receptor-G protein interactions, and regulation of G protein-coupled receptor function.
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