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Molecular Biology of the Neuron$
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R. Wayne Davies and Brian Morris

Print publication date: 2004

Print ISBN-13: 9780198509981

Published to Oxford Scholarship Online: September 2009

DOI: 10.1093/acprof:oso/9780198509981.001.0001

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Genetic basis of human neuronal diseases

Genetic basis of human neuronal diseases

(p.387) Chapter 15 Genetic basis of human neuronal diseases
Molecular Biology of the Neuron

Mark E. S. Bailey

Oxford University Press

This chapter summarizes what is known about the genes underlying a range of human diseases where the causative or associated gene is expressed in neurons and there is a clear primary effect on developing of mature neurons, and illustrates how subsequent studies have illuminated both the pathogenic process and normal neuronal functioning. The topics covered are organized according to a necessarily simplistic view of the functional ontogeny of the nervous system, from early neurogenesis, migration, and pattern formation, through neuronal maturation/differentiation and mature neuronal function, to neurodegeneration and cell death.

Keywords:   human disease, neurons, gene expression, causative gene, associated gene

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