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The Weak Hydrogen Bond: In Structural Chemistry and Biology

Gautam Desiraju and Thomas Steiner

Abstract

The weak hydrogen bond, also known as non-conventional hydrogen bond, has been the subject of intense scrutiny over recent years in several fields, in particular structural chemistry, structural biology, and the pharmaceutical sciences. Today, there is a large body of experimental and theoretical evidence confirming that hydrogen bonds like C-H···O, N-H···π, C-H···π and even bonds like O-H··· metal play distinctive roles in molecular recognition, guiding molecular association, and in determining molecular and supramolecular architectures. The relevant compound classes include organometallic co ... More

Keywords: weak hydrogen bond, structural chemistry, structural biology, pharmaceutical sciences, molecular recognition, molecular association, supramolecular architectures, organometallic complexes, bio-organic systems, proteins

Bibliographic Information

Print publication date: 2001 Print ISBN-13: 9780198509707
Published to Oxford Scholarship Online: January 2010 DOI:10.1093/acprof:oso/9780198509707.001.0001

Authors

Affiliations are at time of print publication.

Gautam Desiraju, author
School of Chemistry, University of Hyderabad, India

Thomas Steiner, author
Institut fuer Kristallographie, Freie Universität Berlin, Germany