The weak hydrogen bond, also known as non-conventional hydrogen bond, has been the subject of intense scrutiny over recent years in several fields, in particular structural chemistry, structural biology, and the pharmaceutical sciences. Today, there is a large body of experimental and theoretical evidence confirming that hydrogen bonds like C-H···O, N-H···π, C-H···π and even bonds like O-H··· metal play distinctive roles in molecular recognition, guiding molecular association, and in determining molecular and supramolecular architectures. The relevant compound classes include organometallic co ... More

The weak hydrogen bond, also known as non-conventional hydrogen bond, has been the subject of intense scrutiny over recent years in several fields, in particular structural chemistry, structural biology, and the pharmaceutical sciences. Today, there is a large body of experimental and theoretical evidence confirming that hydrogen bonds like C-H···O, N-H···π, C-H···π and even bonds like O-H··· metal play distinctive roles in molecular recognition, guiding molecular association, and in determining molecular and supramolecular architectures. The relevant compound classes include organometallic complexes, organic and bio-organic systems, as well as DNA and proteins.