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Lysosomal Disorders of the BrainRecent Advances in Molecular and Cellular Pathogenesis and Treatment$
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Frances Platt and Steven Walkley

Print publication date: 2004

Print ISBN-13: 9780198508786

Published to Oxford Scholarship Online: September 2009

DOI: 10.1093/acprof:oso/9780198508786.001.0001

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Cell-mediated delivery systems

Cell-mediated delivery systems

(p.339) Chapter 14 Cell-mediated delivery systems
Lysosomal Disorders of the Brain

Kostantin Dobrenis

Oxford University Press

Diseases that involve the central nervous system (CNS) pose one of the most difficult challenges in human therapy. Cell-mediated therapy (CMT) is a uniquely complex and powerful approach that offers an unparalleled advantage. This chapter reviews work in the area of CMT with a bias towards understanding the critical mechanisms that underlie successful CMT for CNS storage disease. It highlights the advantages offered by employing cells as the therapeutic agent.

Keywords:   central nervous system, cell-mediated therapy, lysosomal storage disorders, CMT

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