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Human Genome Epidemiology, 2nd EditionBuilding the evidence for using genetic information to improve health and prevent disease$
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Muin Khoury, Sara Bedrosian, Marta Gwinn, Julian Higgins, John Ioannidis, and Julian Little

Print publication date: 2009

Print ISBN-13: 9780195398441

Published to Oxford Scholarship Online: May 2010

DOI: 10.1093/acprof:oso/9780195398441.001.0001

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Coronary heart disease

Coronary heart disease

Chapter:
(p.369) 19 Coronary heart disease
Source:
Human Genome Epidemiology, 2nd Edition
Author(s):

Adam S. Butterworth

Julian P. T. Higgins

Nadeem Sarwar

John Danesh

Publisher:
Oxford University Press
DOI:10.1093/acprof:oso/9780195398441.003.0019

Coronary heart disease (CHD) — which includes myocardial infarction, angina pectoris, and stenosis of the coronary arteries — is the leading cause of death worldwide, with over 7 million deaths per year. The tendency for CHD to cluster in families suggests that genetic variation, either directly or through modulation of known or as yet unidentified risk factors, importantly influences CHD risk. This chapter provides a critical and quantitative review of the current state of evidence regarding potential genetic susceptibility loci and CHD. It reviews published quantitative reviews of candidate gene polymorphisms and published GWAS addressing CHD.

Keywords:   genetic variants, genetic variations, human disease, genome-wide studies, coronary heart disease, risk factors

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