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Human Genome Epidemiology, 2nd EditionBuilding the evidence for using genetic information to improve health and prevent disease$
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Muin Khoury, Sara Bedrosian, Marta Gwinn, Julian Higgins, John Ioannidis, and Julian Little

Print publication date: 2009

Print ISBN-13: 9780195398441

Published to Oxford Scholarship Online: May 2010

DOI: 10.1093/acprof:oso/9780195398441.001.0001

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Integration of the evidence on gene–disease associations: methods of HuGE reviews

Integration of the evidence on gene–disease associations: methods of HuGE reviews

Chapter:
(p.215) 11 Integration of the evidence on gene–disease associations: methods of HuGE reviews
Source:
Human Genome Epidemiology, 2nd Edition
Author(s):

Julian P. T. Higgins

Julian Little

Publisher:
Oxford University Press
DOI:10.1093/acprof:oso/9780195398441.003.0011

Human Genome Epidemiology (HuGE) reviews have been a cornerstone of the efforts of the Human Genome Epidemiology Network (HuGENet) to develop an online resource to house the cumulative and changing information on epidemiologic aspects of human genes. HuGE reviews may collate evidence on population frequencies of genetic variants, genotype-phenotype associations, interactions among genes and between genes, and environmental exposures, or a combination of these. More than 70 HuGE reviews have been completed under the auspices of HuGENet, with more than 80 in preparation at the time of writing. This chapter explains what HuGE reviews aim to achieve and describes some key components of the methodology for undertaking them. The material is also directly relevant to reviews and meta-analysis of genetic association studies undertaken by groups outside of HuGENet.

Keywords:   genetic association studies, gene-disease associations, HuGE, HuGENet, genome-wide association studies

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