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The History of Neuroscience in AutobiographyVolume 7$
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Larry R. Squire

Print publication date: 2011

Print ISBN-13: 9780195396133

Published to Oxford Scholarship Online: January 2012

DOI: 10.1093/acprof:oso/9780195396133.001.0001

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Robert Y. Moore

Robert Y. Moore

Chapter:
Robert Y. Moore
Source:
The History of Neuroscience in Autobiography
Author(s):

Larry R. Squire

Publisher:
Oxford University Press
DOI:10.1093/acprof:oso/9780195396133.003.0012

Robert Moore became intrigued with the concept of localization of function in the brain, and its implications for medicine, as an undergraduate. After early work on the neurobiology of memory, he studied the organization of mammalian auditory and visual systems. This led to studies of the neural control of circadian timing, resulting in discovery of a direct retinohypothalamic tract specialized to mediate entrainment. Subsequent studies showed that selective ablation of the suprachiasmatic nuclei resulted in a loss of circadian function, evidence that the nucleus is a circadian pacemaker, and this has formed a basis for a continuing investigation of a brain circadian timing system. Description and analysis of the circadian timing system has continued in his laboratory along with extensive anatomical studies of the organization of brain systems producing monoamines. Over the last 10 years, he has extended this work to imaging studies of the dopamine systems in Parkinson’s disease. Throughout his career, he has practiced and taught neurology, and care of patients has been an important component of his activities.

Keywords:   circadian, retinohypothalamic tract, suprachiasmatic nucleus, monoamines, dopamine, Parkinson’s disease

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