Terje Lømo discovered long term potentiation (LTP) and with Tim Bliss did the first systematic study of LTP. Lømo discovered that evoked muscle impulse activity per se controlled the properties of muscle fibers outside the neuromuscular junction and provided evidence against the idea of such control by “trophic factors”. He described the normal firing patterns of motor neurons by 24h recordings of single motor unit activity from unrestrained rats and demonstrated the importance of such patterns in controlling the phenotype of muscle fibers with respect to both membrane and contractile properties. He introduced the concept of adaptive ranges, within which muscle fibers adjust their contractile properties to the impulse patterns and hence to the work imposed on them.
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