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The History of Neuroscience in AutobiographyVolume 7$
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Larry R. Squire

Print publication date: 2011

Print ISBN-13: 9780195396133

Published to Oxford Scholarship Online: January 2012

DOI: 10.1093/acprof:oso/9780195396133.001.0001

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Krešimir Krnjevic´

Krešimir Krnjevic´

Krešimir Krnjevic´
The History of Neuroscience in Autobiography

Larry R. Squire

Oxford University Press

Krešimir Krnjević contributed to the identification of main neurotransmitters in the mammalian brain, notably the previously unsuspected transmitter functions of some amino acids – especially glutamate for excitation and GABA for inhibition; also the slower, muscarinic excitation - shown to be mediated by reduction in K conductance – exerted by acetylcholine and liberated in the cortex by ascending cholinergic fibres from the basal forebrain; as well as the opposite hyperpolarizing action of cytoplasmic Ca ions. These were viewed as possible mechanisms of consciousness and anaesthesia.

Keywords:   neurotransmitters, amino acids, glutamate, GABA, acetylcholine, anesthesia

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