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The History of Neuroscience in AutobiographyVolume 7$
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Larry R. Squire

Print publication date: 2011

Print ISBN-13: 9780195396133

Published to Oxford Scholarship Online: January 2012

DOI: 10.1093/acprof:oso/9780195396133.001.0001

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Krešimir Krnjevic´

Krešimir Krnjevic´

Chapter:
Krešimir Krnjevic´
Source:
The History of Neuroscience in Autobiography
Author(s):

Larry R. Squire

Publisher:
Oxford University Press
DOI:10.1093/acprof:oso/9780195396133.003.0007

Krešimir Krnjević contributed to the identification of main neurotransmitters in the mammalian brain, notably the previously unsuspected transmitter functions of some amino acids – especially glutamate for excitation and GABA for inhibition; also the slower, muscarinic excitation - shown to be mediated by reduction in K conductance – exerted by acetylcholine and liberated in the cortex by ascending cholinergic fibres from the basal forebrain; as well as the opposite hyperpolarizing action of cytoplasmic Ca ions. These were viewed as possible mechanisms of consciousness and anaesthesia.

Keywords:   neurotransmitters, amino acids, glutamate, GABA, acetylcholine, anesthesia

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