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The History of Neuroscience in AutobiographyVolume 7$
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Larry R. Squire

Print publication date: 2011

Print ISBN-13: 9780195396133

Published to Oxford Scholarship Online: January 2012

DOI: 10.1093/acprof:oso/9780195396133.001.0001

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Bertil Hille

Bertil Hille

Chapter:
Bertil Hille
Source:
The History of Neuroscience in Autobiography
Author(s):

Larry R. Squire

Publisher:
Oxford University Press
DOI:10.1093/acprof:oso/9780195396133.003.0004

Bertil Hille helped establish the concept of ion channels as membrane proteins forming gated aqueous pores. He showed that Na+ and K+ channels of axons can be distinguished by drugs such as tetrodotoxin and tetraethyl ammonium ion, and that their ionic selectivity can be understood by a limiting pore size, the selectivity filter, and by movements of ions through a series of saturable sites. He showed that local anesthetics enter Na+ channels in a state-dependent manner. In later studies of modulation of ion channels by G-protein coupled receptors he distinguished two new signaling pathways. A fast, pertussis toxin sensitive pathway turned on inward rectifier K+ channels and turned off Ca2+ channels by G protein G(( subunits. A slow, pertussis toxin insensitive pathway turned off some K+ and Ca2+ channels by depleting the plasma membrane phosphoinositide PIP2. Hille wrote the widely used textbook, Ion Channels of Excitable Membranes.

Keywords:   ion channels, member proteins, Na+ channels, G-protein coupled receptors, signaling pathways

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